Charlotte Wesley Holloman was a lyric soprano, classically-trained pianist, and vocal teacher whose singing talents helped her establish a dynamic and internationally-acclaimed career. Holloman was born in Washington, D.C. to Florence Louise Johnson Wesley, a school teacher and Baltimore, Maryland socialite, and Charles H. Wesley, well-known historian and minister. Holloman attended Miners Teachers College for her elementary school years. When her father was awarded a Guggenheim Fellowship, Holloman traveled with her parents and attended Regents Park Elementary School in London, England. After graduating from Dunbar High School in Washington. D.C. in 1937, Holloman entered Howard University and earned a bachelor's degree in music in 1941. Holloman also attended Columbia University, earning a master's degree in voice and music education in 1943.

In the 1950s, Holloman appeared on Broadway, starring in "The Barrier," a musical about racial tensions based on Langston Hughes's work, and "My Darling Aida," a musical about a Southern plantation. Holloman was a featured soloist for recitals world-wide, including London, England and Berlin, Germany. She was a featured soloist for the Dayton Philharmonic, Boston Symphony, and Berkshire Music Festival at the height of her performance career. In 1961, Mrs. Holloman received the Martha Baird Rockefeller Fund for Music grant to pursue voice studies with top instructors in Europe. She was contracted by the Saarbrücken and Essen opera companies in Germany, establishing a repertoire of 22 leading roles through her creation of major operatic characters in more than 13 operas in Germany, England and Italy.

Once Holloman returned to the states, she began a career in higher education. She became an adjunct faculty member of The City University of New York (CUNY), Catholic University of America, Northern Virginia Community College, University of the District of Columbia, and Howard University. In addition to teaching and mentoring students at Howard University for over twenty years, Holloman maintained a private studio and provided vocal lessons up until her death in 2015.